S-Adenosyl-Methionine improves depression in patients with Parkinson's disease in an open-label clinical trial

Mov Disord. 2000 Nov;15(6):1225-9. doi: 10.1002/1531-8257(200011)15:6<1225::aid-mds1025>3.0.co;2-a.

Abstract

We report a pilot study of S-adenosyl-methionine (SAM) in 13 depressed patients with Parkinson's disease. All patients had been previously treated with other antidepressant agents and had no significant benefit or had intolerable side effects. SAM was administered in doses of 800 to 3600 mg per day for a period of 10 weeks. Eleven patients completed the study, and 10 had at least a 50% improvement on the 17-point Hamilton Depression Scale (HDS). One patient did not improve. Two patients prematurely terminated participation in the study because of increased anxiety. One patient experienced mild nausea, and another two patients developed mild diarrhea, which resolved spontaneously. The mean HDS score before treatment was 27.09 +/- 6.04 (mean +/- standard deviation) and was 9.55 +/- 7.29 after SAM treatment (p < 0.0001). Although uncontrolled and preliminary, this study suggests that SAM is well tolerated and may be a safe and effective alternative to the antidepressant agents currently used in patients with Parkinson's disease.

Publication types

  • Clinical Trial

MeSH terms

  • Aged
  • Antidepressive Agents / adverse effects
  • Antidepressive Agents / therapeutic use*
  • Depression / drug therapy*
  • Depression / etiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / complications*
  • Patient Dropouts
  • Pilot Projects
  • Psychiatric Status Rating Scales
  • S-Adenosylmethionine / adverse effects
  • S-Adenosylmethionine / therapeutic use*
  • Treatment Outcome

Substances

  • Antidepressive Agents
  • S-Adenosylmethionine