Abstract
We present a study of a nosocomial outbreak of multidrug-resistant tuberculosis caused by Mycobacterium bovis in 31 patients, 30 of whom were infected with human immunodeficiency virus; all 31 died of progressive tuberculosis. All M. bovis strains had identical spoligotyping patterns and showed resistance to 12 antituberculosis drugs. Reinfection was suggested in 11 cases and confirmed in 4 by molecular typing methods. The causative strain was named "B strain."
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / epidemiology*
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AIDS-Related Opportunistic Infections / microbiology
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AIDS-Related Opportunistic Infections / prevention & control
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Adult
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Antitubercular Agents / pharmacology
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Cross Infection / epidemiology*
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Cross Infection / etiology
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Cross Infection / prevention & control
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Disease Outbreaks*
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Drug Resistance, Multiple
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Female
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Humans
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Male
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Middle Aged
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Mycobacterium bovis / classification
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Mycobacterium bovis / drug effects
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Mycobacterium bovis / genetics*
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Mycobacterium bovis / growth & development
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Pentosyltransferases / genetics
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Recurrence
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Spain / epidemiology
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Tuberculosis, Multidrug-Resistant / epidemiology*
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Tuberculosis, Multidrug-Resistant / etiology
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Tuberculosis, Multidrug-Resistant / prevention & control
Substances
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Antitubercular Agents
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Pentosyltransferases
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arabinosyltransferase