Selegiline completely restores choline acetyltransferase activity deficits in simian immunodeficiency infection

Eur J Pharmacol. 2001 Jan 5;411(1-2):R1-R2. doi: 10.1016/s0014-2999(00)00874-8.

Abstract

Human immunodeficiency virus (HIV) infection is associated with a progressive dementia, in addition to motor and behavioural deficits. Cognitive deterioration and motor impairments have been observed also in simian immunodeficiency virus (SIV)-infected monkeys, an animal model for HIV infection. We found recently that choline acetyltransferase activity is markedly reduced in brains of SIV-infected monkeys. We report now that selegiline, completely restores the reduced choline acetyltransferase activity which encourages for a meaningful anti-dementia therapeutic strategy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / enzymology
  • Choline O-Acetyltransferase / drug effects*
  • Choline O-Acetyltransferase / metabolism
  • Dose-Response Relationship, Drug
  • Hippocampus / drug effects
  • Hippocampus / enzymology
  • Macaca mulatta
  • Monoamine Oxidase Inhibitors / pharmacology*
  • Putamen / drug effects
  • Putamen / enzymology
  • Selegiline / pharmacology*
  • Simian Acquired Immunodeficiency Syndrome / enzymology*
  • Simian Acquired Immunodeficiency Syndrome / virology
  • Simian Immunodeficiency Virus*

Substances

  • Monoamine Oxidase Inhibitors
  • Selegiline
  • Choline O-Acetyltransferase