Squamous-cell carcinoma of the maxillary sinus is an infrequent neoplasm of poor prognosis. Symptoms are evident when the disease is in an advanced stage. Lymph-node metastases are relatively infrequent. The survival rate of patients with this tumor has improved slightly since Obgren reported his experience in 1933, thanks to oncological and surgical advances since then. We report our experience with 28 surgically treated cases of maxillary-sinus squamous-cell carcinoma in the last 10 years, analyzing the reconstructive procedures applied, the disease-free survival rate, and our treatment protocol. A bibliographic review was made to examine all current therapeutic possibilities.