Immunogenicity of pneumococcal vaccine in heart transplant recipients

E A Blumberg; S C Brozena; P Stutman; D Wood; H M Phan; D M Musher

doi:10.1086/318482

Immunogenicity of pneumococcal vaccine in heart transplant recipients

Clin Infect Dis. 2001 Jan 15;32(2):307-10. doi: 10.1086/318482. Epub 2000 Dec 22.

Authors

E A Blumberg¹, S C Brozena, P Stutman, D Wood, H M Phan, D M Musher

Affiliation

¹ Department of Medicine and MCP Hahnemann School of Medicine, Philadelphia, PA, USA. blumbere@mail.med.upenn.edu

PMID: 11170924
DOI: 10.1086/318482

Abstract

To assess the immunogenicity of pneumococcal vaccine in recipients of heart transplants, we immunized 35 long-term transplantation survivors with pneumococcal vaccine and measured the pre- and postvaccination IgG antibody titers to 5 representative vaccine capsular polysaccharides. Responses of heart transplant recipients to pneumococcal vaccine antigens were generally suppressed.

Publication types

Comparative Study

MeSH terms

Adult
Aged
Antibodies, Bacterial / blood
Antibody Formation
Bacterial Capsules / immunology
Female
Heart Transplantation*
Humans
Immunity, Active
Immunoglobulin G / blood
Male
Middle Aged
Pneumococcal Infections / immunology
Pneumococcal Infections / prevention & control*
Pneumococcal Vaccines / administration & dosage*
Streptococcus pneumoniae / immunology
Vaccination*

Substances

Antibodies, Bacterial
Immunoglobulin G
Pneumococcal Vaccines