Mechanisms of myelopoiesis stimulation with pantohematogen and granulocyte colony-stimulating factor during cytostatic myelosuppression

E D Gol'dberg; A M Dygai; L A Gur'yantseva; V V Zhdanov; N S Pozhen'ko; E V Simanina; N I Suslov; T Y Khrichkova; E V Udut; V E Gol'dberg; M G Matyash; N O Popova

Mechanisms of myelopoiesis stimulation with pantohematogen and granulocyte colony-stimulating factor during cytostatic myelosuppression

Bull Exp Biol Med. 2000 Nov;130(11):1051-4.

Authors

E D Gol'dberg¹, A M Dygai, L A Gur'yantseva, V V Zhdanov, N S Pozhen'ko, E V Simanina, N I Suslov, T Y Khrichkova, E V Udut, V E Gol'dberg, M G Matyash, N O Popova

Affiliation

¹ Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.

PMID: 11182813

Abstract

We compared hemopoiesis-stimulating activities of dry pantohematogen and recombinant granulocyte colony-stimulating factor under conditions of cyclophosphamide-induced myelosuppression. These preparations stimulated regeneration of bone marrow granulomonocytopoiesis by various mechanisms.

MeSH terms

Allergens / pharmacology*
Animals
Antineoplastic Agents, Alkylating / pharmacology*
Biological Factors*
Cyclophosphamide / pharmacology*
Granulocyte Colony-Stimulating Factor / pharmacology*
Granulocytes / drug effects
Leukopoiesis / drug effects*
Mice
Mice, Inbred CBA
Monocytes / drug effects
Recombinant Proteins

Substances

Allergens
Antineoplastic Agents, Alkylating
Biological Factors
Recombinant Proteins
pantohematogen
Granulocyte Colony-Stimulating Factor
Cyclophosphamide