Efficacy of amphotericin B colloidal dispersion in the treatment of Mediterranean visceral leishmaniasis in immunocompetent adult patients

G B Gaeta; A Maisto; D Di Caprio; A Scalone; G Pasquale; F M Felaco; D Galante; L Gradoni

doi:10.1080/003655400459612

Efficacy of amphotericin B colloidal dispersion in the treatment of Mediterranean visceral leishmaniasis in immunocompetent adult patients

Scand J Infect Dis. 2000;32(6):675-7. doi: 10.1080/003655400459612.

Authors

G B Gaeta¹, A Maisto, D Di Caprio, A Scalone, G Pasquale, F M Felaco, D Galante, L Gradoni

Affiliation

¹ Dipartimento di Malattie Infettive, Seconda Università, Naples, Italy.

PMID: 11200380
DOI: 10.1080/003655400459612

Abstract

Twelve immunocompetent adults with Mediterranean visceral leishmaniasis (VL) were treated with amphotericin B colloidal dispersion (ABCD; 2 mg/kg/d for 7 d). All patients showed rapid clinical response without significant adverse events. Two weeks after therapy they were parasitologically cured and no relapses occurred during 6 months. ABCD is a valid alternative in the management of Mediterranean VL in adult patients.

MeSH terms

Adult
Aged
Amphotericin B / administration & dosage
Amphotericin B / adverse effects
Amphotericin B / therapeutic use*
Antiprotozoal Agents / administration & dosage
Antiprotozoal Agents / adverse effects
Antiprotozoal Agents / therapeutic use*
Female
Humans
Immunocompetence
Leishmaniasis, Visceral / drug therapy*
Leishmaniasis, Visceral / immunology
Male
Middle Aged
Treatment Outcome

Substances

Antiprotozoal Agents
Amphotericin B