Synthesis and properties of 2-(4-substituted)butyl derivatives of some 2,3-dihydro-1,3-dioxo-1H-pyrrolo[3,4-c]pyridines

Pharmazie. 2001 Feb;56(2):133-8.

Abstract

The synthesis of 2-(4-substituted)butyl derivatives of 4-alkoxy-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine (10-15) and the results of preliminary pharmacological screening are described in this paper. All the compounds tested showed a strong analgesic action, suppressed spontaneous locomotor activity and prolonged barbiturate sleep. Except 10, all significantly decreased systolic and diastolic blood pressure.

MeSH terms

  • Analgesics, Non-Narcotic / chemical synthesis
  • Analgesics, Non-Narcotic / pharmacology
  • Analgesics, Non-Narcotic / toxicity
  • Animals
  • Barbiturates / pharmacology
  • Blood Pressure / drug effects
  • Central Nervous System Depressants / chemical synthesis*
  • Central Nervous System Depressants / pharmacology*
  • Central Nervous System Depressants / toxicity
  • Hypnotics and Sedatives / pharmacology
  • Lethal Dose 50
  • Magnetic Resonance Spectroscopy
  • Mice
  • Motor Activity / drug effects
  • Pain Measurement / drug effects
  • Pyridines / chemistry*
  • Pyridines / pharmacology*
  • Pyridines / toxicity
  • Pyrroles / chemistry*
  • Pyrroles / pharmacology*
  • Pyrroles / toxicity
  • Rats
  • Reaction Time / drug effects
  • Sleep / drug effects
  • Spectrophotometry, Infrared
  • Thiopental / pharmacology

Substances

  • Analgesics, Non-Narcotic
  • Barbiturates
  • Central Nervous System Depressants
  • Hypnotics and Sedatives
  • Pyridines
  • Pyrroles
  • Thiopental