Amplification of AML1 in childhood acute lymphoblastic leukemias

P Dal Cin; L Atkins; C Ford; S Ariyanayagam; S A Armstrong; R George; A Cleary; C C Morton

doi:10.1002/1098-2264(2001)9999:9999<::aid-gcc1107>3.0.co;2-c

Amplification of AML1 in childhood acute lymphoblastic leukemias

Genes Chromosomes Cancer. 2001 Apr;30(4):407-9. doi: 10.1002/1098-2264(2001)9999:9999<::aid-gcc1107>3.0.co;2-c.

Authors

P Dal Cin¹, L Atkins, C Ford, S Ariyanayagam, S A Armstrong, R George, A Cleary, C C Morton

Affiliation

¹ Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. pdalcin@rics.bwh.harvard.edu

PMID: 11241794
DOI: 10.1002/1098-2264(2001)9999:9999<::aid-gcc1107>3.0.co;2-c

Abstract

Amplification of AML1 has been confirmed by fluorescence in situ hybridization analysis in two cases of childhood acute lymphoblastic leukemia. It remains to be elucidated whether this amplification results in up-regulation of the normal AML1 gene product or a potentially mutant AML1 transcript.

Publication types

Case Reports

MeSH terms

Child
Chromosome Banding
Core Binding Factor Alpha 2 Subunit
DNA-Binding Proteins / genetics*
Female
Gene Amplification / genetics*
Humans
In Situ Hybridization, Fluorescence
Male
Neoplasm Proteins / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Proto-Oncogene Proteins / genetics
Transcription Factors / genetics*

Substances

Core Binding Factor Alpha 2 Subunit
DNA-Binding Proteins
Neoplasm Proteins
Proto-Oncogene Proteins
RUNX1 protein, human
Transcription Factors