Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase alpha and beta

Bioorg Med Chem. 2001 Feb;9(2):367-76. doi: 10.1016/s0968-0896(00)00252-2.

Abstract

Sulfoquinovosyldiacylglycerols (SQDGs) and sulfoquinovosylmonoacylglycerols (SQMGs), bearing diverse fatty acids, were synthesized from D-glucose, and were examined for enzymatic inhibitions of DNA polymerase alpha and beta. These results indicated that the carbon numbers of the fatty acids were highly related to the activities, at least in vitro, of eukaryotic DNA polymerase inhibition.

MeSH terms

  • Animals
  • Anti-HIV Agents / chemical synthesis
  • Anti-HIV Agents / pharmacology
  • Combinatorial Chemistry Techniques
  • DNA Polymerase I / antagonists & inhibitors*
  • DNA Polymerase beta / antagonists & inhibitors*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Eukaryotic Cells / enzymology
  • Glycolipids / chemical synthesis
  • Glycolipids / pharmacology*
  • Humans
  • Inhibitory Concentration 50
  • Structure-Activity Relationship

Substances

  • Anti-HIV Agents
  • Enzyme Inhibitors
  • Glycolipids
  • sulfoquinovosyl diglyceride
  • DNA Polymerase I
  • DNA Polymerase beta