Toxicological and forensic medical characteristics of capsaicinoids are presented. Capsaicinoids represent a mixture of three basic compounds with similar structure: capsaicine, dihydrocapsaicine, and nordihydrocapsaicine, all of which are the primary components of red pepper extract (Oleoresin Capsicum). The advantages of this group of irritants in comparison with synthetic irritants are discussed. Probable routes of administration of the extract with regard to its hazard for the organism are considered. Results of experimental studies on nonbiological phantoms and volunteers are presented.