Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome

K Michizono; F Umehara; T Hashiguchi; K Arimura; E Matsuura; O Watanabe; N Fujimoto; Y Okada; M Osame

doi:10.1212/wnl.56.6.807

Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome

Neurology. 2001 Mar 27;56(6):807-10. doi: 10.1212/wnl.56.6.807.

Authors

K Michizono¹, F Umehara, T Hashiguchi, K Arimura, E Matsuura, O Watanabe, N Fujimoto, Y Okada, M Osame

Affiliation

¹ Third Department of Internal Medicine, Kagoshima University School of Medicine, Japan.

PMID: 11274326
DOI: 10.1212/wnl.56.6.807

Abstract

The authors quantitatively measured levels of matrix metalloproteinases (MMP), tissue inhibitor of metalloproteinases (TIMP), and vascular endothelial growth factor (VEGF) in blood samples of POEMS syndrome. Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 were more increased in patients with POEMS syndrome than in patients with other neurologic disorders or in healthy controls. Serum levels of VEGF and TIMP-1 were strongly correlated with each other. Increased circulating levels of MMP-1, -2, -3, -9, and TIMP-1 may lead to a better understanding the pathogenesis of POEMS syndrome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Endothelial Growth Factors / blood
Immunoenzyme Techniques
Lymphokines / blood
Matrix Metalloproteinase 1 / blood*
Matrix Metalloproteinase 2 / blood*
Matrix Metalloproteinase 3 / blood*
Matrix Metalloproteinase 9 / blood*
POEMS Syndrome / blood*
Tissue Inhibitor of Metalloproteinase-1 / blood*
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors

Substances

Endothelial Growth Factors
Lymphokines
Tissue Inhibitor of Metalloproteinase-1
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Matrix Metalloproteinase 3
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Matrix Metalloproteinase 1