Cytotoxic T cells and mycobacteria

C L Silva; V L Bonato; K M Lima; A A Coelho-Castelo; L H Faccioli; A Sartori; A O De Souza; S C Leão

doi:10.1111/j.1574-6968.2001.tb10575.x

Cytotoxic T cells and mycobacteria

FEMS Microbiol Lett. 2001 Apr 1;197(1):11-8. doi: 10.1111/j.1574-6968.2001.tb10575.x.

Authors

C L Silva¹, V L Bonato, K M Lima, A A Coelho-Castelo, L H Faccioli, A Sartori, A O De Souza, S C Leão

Affiliation

¹ Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. clsilva@fmrp.usp.br

PMID: 11287139
DOI: 10.1111/j.1574-6968.2001.tb10575.x

Abstract

How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to enhance this.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bacterial Proteins*
Bacterial Vaccines / administration & dosage
Bacterial Vaccines / immunology
Chaperonin 60
Chaperonins / genetics
Chaperonins / immunology*
Humans
Macrophage Activation / immunology
Mice
Mycobacterium tuberculosis / genetics
Mycobacterium tuberculosis / immunology*
Rats
Rats, Inbred Lew
T-Lymphocytes, Cytotoxic / immunology*
Tuberculosis / immunology
Tuberculosis / microbiology
Tuberculosis / prevention & control*
Vaccines, DNA / administration & dosage
Vaccines, DNA / immunology*

Substances

Bacterial Proteins
Bacterial Vaccines
Chaperonin 60
Vaccines, DNA
heat-shock protein 65, Mycobacterium
Chaperonins