Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists

J Med Chem. 2001 Apr 26;44(9):1337-40. doi: 10.1021/jm0108505.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aporphines / chemical synthesis*
  • Aporphines / chemistry
  • Aporphines / pharmacology
  • Binding, Competitive
  • Brain / metabolism
  • CHO Cells
  • Cricetinae
  • Crystallography, X-Ray
  • Cyclic AMP / biosynthesis
  • In Vitro Techniques
  • Molecular Conformation
  • Rats
  • Receptors, Serotonin / drug effects*
  • Serotonin Antagonists / chemical synthesis*
  • Serotonin Antagonists / chemistry
  • Serotonin Antagonists / pharmacology
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Aporphines
  • Receptors, Serotonin
  • Serotonin Antagonists
  • serotonin 7 receptor
  • Cyclic AMP