Preparation of a water-soluble fluorinated zinc phthalocyanine and its effect for photodynamic therapy

J Photochem Photobiol B. 2000 Dec;59(1-3):20-5. doi: 10.1016/s1011-1344(00)00129-9.

Abstract

An amphiphilic fluorinated phthalocyanine, zinc tetracarboxyoctafluorophthalocyanine (ZnC4F8Pc) was synthesized and characterized. Its photodynamic efficiency for HeLa cells was compared with hydrophilic zinc octacarboxyphthalocyanine (ZnC8Pc) and hydrophobic zinc hexadecafluorophthalocyanine (ZnF16Pc). ZnC4F8Pc had a remarkable photodynamic effect among the phthalocyanines used. The effect is apparently caused by the fact that ZnC4F8Pc is mainly accumulated in the hydrophobic lipid membrane and is in the photoactive monomer form in HeLa cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorine
  • HeLa Cells
  • Humans
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Indoles / metabolism
  • Isoindoles
  • Lipid Peroxidation
  • Organometallic Compounds / chemistry*
  • Photochemotherapy
  • Photosensitizing Agents / chemical synthesis*
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / metabolism
  • Solubility
  • Solvents
  • Water
  • Zinc Compounds

Substances

  • Indoles
  • Isoindoles
  • Organometallic Compounds
  • Photosensitizing Agents
  • Solvents
  • Zinc Compounds
  • zinc tetracarboxyoctafluorophthalocyanine
  • Water
  • Zn(II)-phthalocyanine
  • Fluorine