Abstract
Here we review the history, clinical significance, pathology and molecular pathogenesis of Citrobacter rodentium, the causative agent of transmissible murine colonic hyperplasia. C. rodentium serves as an important model pathogen for investigating the mechanisms controlling attaching and effacing pathology, epithelial hyperproliferation, and tumor promotion in the distal colon of the mouse.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Citrobacter freundii / genetics
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Citrobacter freundii / pathogenicity*
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Cocarcinogenesis
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Colon / microbiology
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Colon / pathology*
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Colonic Diseases / microbiology
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Colonic Diseases / pathology*
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Colonic Neoplasms / etiology
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Disease Models, Animal
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Enterobacteriaceae Infections / microbiology
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Enterobacteriaceae Infections / pathology*
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Humans
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Hyperplasia
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Mice
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Virulence / genetics