Use of mechanical ventilation has increased in recent years and constitutes a major therapeutic modality in the intensive care unit (ICU). In the recent years, changes in the ventilatory modes, in the ventilatory strategies and in the weaning from mechanical ventilation have occurred. We have compared the data obtained from the Spanish ICUs in studies that were carried out in three periods of the nineties, with the aim to test whether the aforementioned innovations have modified the clinical practice. We analyzed demographic data, primary reason for mechanical ventilation, ventilatory parameters, mode of weaning and performance of tracheostomy. It was observed a decrease in the percentage of patients receiving mechanical ventilation. There was a significant trend to ventilate older patients over the course of the decade. In the mode of ventilation, we observed a significant decrease in the use of the synchronized intermittent mandatory ventilation with a increment in the use of assist-control ventilation. We did not find differences in the ventilatory settings. Concerning to weaning, over the course of the decade occurred an increase in use of pressure support ventilation and spontaneous breathing trial, being this method the most frequently used at the end of the decade. The performance of the tracheostomy has been lesser and earlier over the time. The results obtained suggest that findings from research on mechanical ventilation are incorporated into clinical practice at a very slow pace whereas the evidence obtained from the clinical trials about weaning has had a better reception.