Decreased hippocampal BDNF expression after acute systemic injection of quinpirole

Neuropharmacology. 2001 Jun;40(7):954-7. doi: 10.1016/s0028-3908(01)00017-x.

Abstract

We report that acute quinpirole injection reduces BDNF mRNA levels in the rat hippocampus both at 2 and 6 h after the administration. These results suggest that the neurotrophin expression may be inhibited by situations involving dopaminergic overactivity.

MeSH terms

  • Animals
  • Brain-Derived Neurotrophic Factor / drug effects*
  • Brain-Derived Neurotrophic Factor / metabolism
  • Dopamine Agonists / pharmacology*
  • Hippocampus / drug effects*
  • Hippocampus / metabolism
  • Male
  • Quinpirole / pharmacology*
  • RNA, Messenger / drug effects
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D2 / drug effects
  • Receptors, Dopamine D2 / metabolism

Substances

  • Brain-Derived Neurotrophic Factor
  • Dopamine Agonists
  • RNA, Messenger
  • Receptors, Dopamine D2
  • Quinpirole