Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate

Parasitol Res. 2001 Jun;87(6):449-52. doi: 10.1007/s004360000359.

Abstract

The efficacies of diloxanide furoate, beta-cyclodextrin and a cyclodextrin inclusion complex against Cryptosporidium parvum were evaluated in a suckling murine model. Efficacy was established by numbers of oocysts recovered from the intestinal tract of mice on day 7 postinfection. The level of infection in treated mice was significantly lower than in control mice and, surprisingly, the most efficacious treatment was beta-cyclodextrin, an excipient used in pharmaceutical technology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amebicides / therapeutic use*
  • Animals
  • Cattle
  • Cryptosporidiosis / drug therapy*
  • Cryptosporidiosis / parasitology
  • Cryptosporidium parvum / isolation & purification*
  • Cryptosporidium parvum / physiology
  • Cyclodextrins / therapeutic use*
  • Disease Models, Animal
  • Drug Carriers
  • Drug Therapy, Combination
  • Excipients
  • Furans / therapeutic use*
  • Mice
  • Parasite Egg Count
  • beta-Cyclodextrins*

Substances

  • Amebicides
  • Cyclodextrins
  • Drug Carriers
  • Excipients
  • Furans
  • beta-Cyclodextrins
  • betadex
  • diloxanide furoate