Abstract
Expression of mIgM was thought to be esential for the differentiation of B cells expressing antibodies of other classes. New evidence suggests isotype class switching to IgA can occur in the absence of mIgM.
MeSH terms
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Animals
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B-Lymphocytes / immunology*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / immunology
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Immunoglobulin A / biosynthesis*
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Immunoglobulin Class Switching / immunology*
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Immunoglobulin Constant Regions / genetics
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Immunoglobulin Constant Regions / immunology
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Immunoglobulin Isotypes
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Immunoglobulin M / genetics
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Immunoglobulin M / immunology*
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Immunoglobulin delta-Chains / genetics
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Immunoglobulin delta-Chains / immunology
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Immunoglobulin epsilon-Chains / genetics
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Immunoglobulin epsilon-Chains / immunology
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Immunoglobulin mu-Chains / genetics
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Immunoglobulin mu-Chains / immunology
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Intestines / cytology*
Substances
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DNA-Binding Proteins
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Immunoglobulin A
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Immunoglobulin Constant Regions
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Immunoglobulin Isotypes
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Immunoglobulin M
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Immunoglobulin delta-Chains
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Immunoglobulin epsilon-Chains
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Immunoglobulin mu-Chains
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V(D)J recombination activating protein 2