[Evaluation of prednisone treatment in children with IgA nephropathy and Schönlein-Henoch nephropathy according to the Waldo protocol with regard to pathomorphologic changes in renal biopsy]

Pol Merkur Lekarski. 2001 Apr;10(58):259-62.
[Article in Polish]

Abstract

The aim of the study was to analyse effectiveness of long term alternate-day prednisone treatment according the protocol of Waldo (Pediatr. Nephrol. 1993, 7, 529) in children with IgA nephropathy (IgAN) and Schönlein-Henoch nephritis (HSN). Eight pts: 6 with IgAN, mean age 10.1 yrs and 2 with HSN aged 10.3 and 14.3 yrs were treated with use of alternate-day prednisone for 2.3 to 3.92 (mean 2.90 yrs). Renal biopsies were performed in all patients 2 to 72 (mean 16 mths) after onset and were graded according the classification of WHO. All pts had normal serum creatinine concentrations at presentation. 3 pts had proteinuria > 1 g/1.73 m2 per day at onset and 5 pts had macroscopic or microscopic haematuria and/or increased proteinuria and/or III grade WHO in renal biopsy. After treatment haematuria and proteinuria disappeared in 2 pts and decreased in 6 pts. Hypertension (2/8), hypercalciuria (2/8), mild weight gain (6/8) and low bone density in lumbar region (5/8) were observed during the treatment.

Conclusions: 1. Long term alternate-day prednisone treatment according the protocol of Waldo allows to decrease haematuria and proteinuria in children with IgAN and HSN 2. Side effects of therapy were observed in 62.5% pts.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Anti-Inflammatory Agents / therapeutic use*
  • Biopsy
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Glomerulonephritis, IGA / drug therapy*
  • Glomerulonephritis, IGA / pathology
  • Hematuria / etiology
  • Hematuria / prevention & control
  • Humans
  • IgA Vasculitis / complications*
  • Kidney / pathology*
  • Nephritis / drug therapy*
  • Nephritis / etiology
  • Nephritis / pathology
  • Prednisone / adverse effects
  • Prednisone / therapeutic use*
  • Proteinuria / etiology
  • Proteinuria / prevention & control
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents
  • Prednisone