Report of three cases of circulating heparin-like anticoagulants

Am J Hematol. 2001 Aug;67(4):256-8. doi: 10.1002/ajh.1126.

Abstract

Clinically significant endogenous circulating heparin-like anticoagulant activity has been associated with hematological malignancies, liver damage, and other pathological conditions. The source of high plasma concentrations of endogenous heparin-like anticoagulants is poorly understood. We report three cases of circulating heparin-like anticoagulants in three patients with hematological malignancies: CLL, multiple myeloma, and T-prolymphocytic leukemia. The severity of bleeding in our patients ranged from severe epistaxis and deep-site hematoma to bleeding of biopsy site and occasional ecchymosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anticoagulants / blood*
  • Hematologic Neoplasms / blood*
  • Hematologic Neoplasms / complications
  • Hemorrhage / etiology
  • Heparin / blood*
  • Humans
  • Male
  • Middle Aged
  • Thrombin Time

Substances

  • Anticoagulants
  • Heparin