Increased extraction of endothelin-1 across the failing human heart

E R Azevedo; D J Stewart; J D Parker

doi:10.1016/s0002-9149(01)01618-6

Increased extraction of endothelin-1 across the failing human heart

Am J Cardiol. 2001 Jul 15;88(2):180-2, A6. doi: 10.1016/s0002-9149(01)01618-6.

Authors

E R Azevedo¹, D J Stewart, J D Parker

Affiliation

¹ Mount Sinai Hospital, Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

PMID: 11448420
DOI: 10.1016/s0002-9149(01)01618-6

Abstract

In this study we compared the transcardiac gradient of plasma endothelin-1 in patients with normal ventricular function and in those with congestive heart failure. We documented a significant reduction in the plasma levels of endothelin-1 across the failing human heart, an effect not seen in patients with normal left ventricular function.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Endothelin-1 / blood*
Endothelin-1 / metabolism
Female
Heart Failure / blood*
Heart Failure / metabolism
Humans
Male
Middle Aged
Myocardium / metabolism
Ventricular Function, Left / physiology

Substances

Endothelin-1