Overexpression of Id-1 protein is a marker for unfavorable prognosis in early-stage cervical cancer

Cancer Res. 2001 Aug 1;61(15):5703-6.

Abstract

Inhibitor of differentiation/DNA binding (Id) proteins are transcription factors, involved in cell cycle regulation and neoangiogenesis. Using immunohistochemistry, we investigated the prognostic influence of Id-1, Id-2, and Id-3 expression in 89 patients with cervical cancer stage pT(1b). In univariate and multivariate analysis, patients with strong or moderate expression of Id-1 had a significant shorter overall survival time (P = 0.0144, log-rank test) and disease-free survival time (P = 0.0107, log-rank test) compared with those with low or absent Id-1 expression. Id-1 expression is an independent prognostic marker in early-stage cervical cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / biosynthesis*
  • Biomarkers, Tumor / physiology
  • DNA-Binding Proteins / biosynthesis*
  • DNA-Binding Proteins / physiology
  • Female
  • Humans
  • Immunohistochemistry
  • Inhibitor of Differentiation Protein 1
  • Inhibitor of Differentiation Protein 2
  • Inhibitor of Differentiation Proteins
  • Microcirculation
  • Multivariate Analysis
  • Neoplasm Proteins*
  • Neoplasm Staging
  • Neovascularization, Pathologic / metabolism
  • Prognosis
  • Repressor Proteins*
  • Survival Rate
  • Transcription Factors / biosynthesis*
  • Transcription Factors / physiology
  • Uterine Cervical Neoplasms / blood supply
  • Uterine Cervical Neoplasms / metabolism*
  • Uterine Cervical Neoplasms / pathology

Substances

  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • ID1 protein, human
  • ID2 protein, human
  • Inhibitor of Differentiation Protein 1
  • Inhibitor of Differentiation Protein 2
  • Inhibitor of Differentiation Proteins
  • Neoplasm Proteins
  • Repressor Proteins
  • Transcription Factors
  • ID3 protein, human