Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability

FASEB J. 2001 Aug;15(10):1771-3. doi: 10.1096/fj.00-0893fje.
No abstract available

MeSH terms

  • Animals
  • Aorta
  • Cattle
  • Cyclic GMP / analysis
  • Dehydroepiandrosterone / pharmacology
  • Endothelium, Vascular / metabolism*
  • Enzyme Inhibitors / pharmacology
  • Glucosephosphate Dehydrogenase / antagonists & inhibitors*
  • Glucosephosphate Dehydrogenase / genetics
  • Glucosephosphate Dehydrogenase / metabolism
  • Hydrogen Peroxide / pharmacology
  • NADP / metabolism
  • Nitric Oxide / metabolism*
  • Nitric Oxide Synthase / antagonists & inhibitors
  • Nitric Oxide Synthase / metabolism
  • Nitric Oxide Synthase Type III
  • Oligonucleotides, Antisense / genetics
  • Oligonucleotides, Antisense / pharmacology
  • Oxidative Stress*
  • Pteridines / pharmacology
  • Pterins*
  • Reactive Oxygen Species / metabolism
  • Transfection

Substances

  • Enzyme Inhibitors
  • Oligonucleotides, Antisense
  • Pteridines
  • Pterins
  • Reactive Oxygen Species
  • Nitric Oxide
  • Dehydroepiandrosterone
  • NADP
  • Hydrogen Peroxide
  • sepiapterin
  • Glucosephosphate Dehydrogenase
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type III
  • Cyclic GMP