Measurement of covalent drug-DNA interactions at the nucleotide level in cells at pharmacologically relevant doses

Methods Enzymol. 2001:340:358-76. doi: 10.1016/s0076-6879(01)40431-9.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology
  • Base Sequence
  • Binding Sites
  • DNA / chemistry
  • DNA / drug effects
  • DNA / genetics
  • DNA / metabolism
  • DNA Adducts / analysis*
  • DNA Damage
  • DNA Primers / genetics
  • DNA, Neoplasm / chemistry
  • DNA, Neoplasm / drug effects
  • DNA, Neoplasm / genetics
  • DNA, Neoplasm / metabolism
  • Humans
  • In Vitro Techniques
  • Polymerase Chain Reaction / methods*

Substances

  • Antineoplastic Agents
  • DNA Adducts
  • DNA Primers
  • DNA, Neoplasm
  • DNA