Synthetic transformations of eleutherobin reveal new features of its microtubule-stabilizing pharmacophore

J Am Chem Soc. 2001 Sep 5;123(35):8632-3. doi: 10.1021/ja016459q.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkaloids / chemical synthesis*
  • Alkaloids / metabolism
  • Alkaloids / pharmacology
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology
  • Cattle
  • Diterpenes*
  • Microtubules / drug effects
  • Structure-Activity Relationship
  • Tubulin / metabolism

Substances

  • Alkaloids
  • Antineoplastic Agents
  • Diterpenes
  • Tubulin
  • eleutherobin