New bioactive chalcones in propolis from El Salvador

Z Naturforsch C J Biosci. 2001 Jul-Aug;56(7-8):593-6. doi: 10.1515/znc-2001-7-819.

Abstract

2',3'-Dihydroxy-4,4'-dimethoxychalcone (1) and 2',3',4-trihydroxy-4'-methoxy-chalcone, two new chalcones, were isolated from propolis from El Salvador. The compounds showed significant antibacterial and antifungal activity and moderate toxicity to Artemia salina nauplii.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Artemia*
  • Caffeic Acids / toxicity
  • Candida albicans / drug effects
  • Chalcone / chemistry*
  • Chalcone / isolation & purification
  • Chalcone / toxicity
  • Chromatography, Thin Layer
  • El Salvador
  • Escherichia coli / drug effects
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Propiophenones / chemistry*
  • Propiophenones / isolation & purification
  • Propiophenones / toxicity
  • Propolis / chemistry*
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal Agents
  • Caffeic Acids
  • Propiophenones
  • Chalcone
  • Propolis
  • caffeic acid