Integrin tyrosine phosphorylation in platelet signaling

Curr Opin Cell Biol. 2001 Oct;13(5):546-54. doi: 10.1016/s0955-0674(00)00250-7.

Abstract

The beta 3 integrin cytoplasmic tyrosine (ICY) motif of alpha IIb beta 3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the beta-integrin cytoplasmic domain. Platelets from mice lacking beta 3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of beta 3-integrin signals.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Adaptor Proteins, Vesicular Transport*
  • Amino Acid Sequence
  • Animals
  • Antigens, CD / chemistry
  • Antigens, CD / metabolism*
  • Blood Platelets / physiology*
  • Integrin beta3
  • Mice
  • Molecular Sequence Data
  • Myosins / metabolism
  • Phosphorylation
  • Phosphotyrosine / metabolism
  • Platelet Adhesiveness
  • Platelet Aggregation*
  • Platelet Glycoprotein GPIIb-IIIa Complex / chemistry
  • Platelet Glycoprotein GPIIb-IIIa Complex / metabolism*
  • Platelet Membrane Glycoproteins / chemistry
  • Platelet Membrane Glycoproteins / metabolism*
  • Proteins / metabolism
  • Shc Signaling Adaptor Proteins
  • Signal Transduction
  • Src Homology 2 Domain-Containing, Transforming Protein 1

Substances

  • Adaptor Proteins, Signal Transducing
  • Adaptor Proteins, Vesicular Transport
  • Antigens, CD
  • Integrin beta3
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Membrane Glycoproteins
  • Proteins
  • Shc Signaling Adaptor Proteins
  • Shc1 protein, mouse
  • Src Homology 2 Domain-Containing, Transforming Protein 1
  • Phosphotyrosine
  • Myosins