Abstract
The beta 3 integrin cytoplasmic tyrosine (ICY) motif of alpha IIb beta 3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the beta-integrin cytoplasmic domain. Platelets from mice lacking beta 3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of beta 3-integrin signals.
MeSH terms
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Adaptor Proteins, Signal Transducing*
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Adaptor Proteins, Vesicular Transport*
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Amino Acid Sequence
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Animals
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Antigens, CD / chemistry
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Antigens, CD / metabolism*
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Blood Platelets / physiology*
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Integrin beta3
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Mice
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Molecular Sequence Data
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Myosins / metabolism
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Phosphorylation
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Phosphotyrosine / metabolism
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Platelet Adhesiveness
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Platelet Aggregation*
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Platelet Glycoprotein GPIIb-IIIa Complex / chemistry
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Platelet Glycoprotein GPIIb-IIIa Complex / metabolism*
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Platelet Membrane Glycoproteins / chemistry
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Platelet Membrane Glycoproteins / metabolism*
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Proteins / metabolism
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Shc Signaling Adaptor Proteins
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Signal Transduction
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Src Homology 2 Domain-Containing, Transforming Protein 1
Substances
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Adaptor Proteins, Signal Transducing
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Adaptor Proteins, Vesicular Transport
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Antigens, CD
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Integrin beta3
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Platelet Glycoprotein GPIIb-IIIa Complex
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Platelet Membrane Glycoproteins
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Proteins
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Shc Signaling Adaptor Proteins
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Shc1 protein, mouse
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Src Homology 2 Domain-Containing, Transforming Protein 1
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Phosphotyrosine
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Myosins