Donor-recipient incompatibility at CD31-codon 563 is a major risk factor for acute graft-versus-host disease after allogeneic bone marrow transplantation from a human leucocyte antigen-matched donor

Br J Haematol. 2001 Sep;114(4):951-3. doi: 10.1046/j.1365-2141.2001.03035.x.

Abstract

Disparities at minor histocompatibility antigens (mHA) are thought to be responsible for acute graft-versus-host disease (aGVHD) in patients receiving bone marrow transplantation (BMT) from a human leucocyte antigen (HLA)-matched donor. Although some mHA have been identified in humans, their role in aGVHD has not. Patients (n = 150) receiving a BMT from an HLA-matched donor were investigated for a correlation between aGVHD and donor/recipient incompatibility for seven polymorphisms previously proposed for mHA (HA-1, H-Y, CD31-codon 125, CD31-codon 563, HPA-1, HPA-3 and HPA-5). Only mismatch at CD31-codon 563 predicted grade II-IV aGVHD. The risk derived from CD31-codon 563 mismatch was the same as that derived from the use of bone marrow from an unrelated donor. We suggest that donor/recipient compatibility at CD31-codon 563 should be added to HLA-typing for donor selection and/or adjustment of aGVHD prophylaxis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Bone Marrow Transplantation
  • Female
  • Graft vs Host Disease / etiology*
  • Humans
  • Leukemia / immunology*
  • Leukemia / therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / immunology
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
  • Leukemia, Myeloid / immunology
  • Leukemia, Myeloid / therapy
  • Logistic Models
  • Male
  • Middle Aged
  • Minor Histocompatibility Antigens / immunology*
  • Myelodysplastic Syndromes / immunology*
  • Myelodysplastic Syndromes / therapy
  • Platelet Endothelial Cell Adhesion Molecule-1 / genetics*
  • Polymorphism, Genetic*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Transplantation Immunology
  • Transplantation, Homologous

Substances

  • Minor Histocompatibility Antigens
  • Platelet Endothelial Cell Adhesion Molecule-1