Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation

B Afessa; M R Litzow; A Tefferi

doi:10.1038/sj.bmt.1703142

Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation

Bone Marrow Transplant. 2001 Sep;28(5):425-34. doi: 10.1038/sj.bmt.1703142.

Authors

B Afessa¹, M R Litzow, A Tefferi

Affiliation

¹ Division of Pulmonary and Critical Care, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

PMID: 11593314
DOI: 10.1038/sj.bmt.1703142

Abstract

Pulmonary complications develop in 30-60% of hematopoietic stem cell transplants (HSCT). The main, late onset, non-infectious complications include Bronchiolitis obliterans (BO), Bronchiolitis obliterans organizing pneumonia (BOOP), and idiopathic pneumonia syndrome (IPS). BO and BOOP occur almost exclusively in allogeneic HSCT, and have 61% and 21% mortality rates, respectively. BOOP responds favorably to corticosteroids. IPS has less than 15% 1-year survival.

Publication types

Review

MeSH terms

Bronchiolitis Obliterans / etiology*
Bronchiolitis Obliterans / mortality
Cryptogenic Organizing Pneumonia / etiology
Cryptogenic Organizing Pneumonia / mortality
Hematopoietic Stem Cell Transplantation / adverse effects*
Hematopoietic Stem Cell Transplantation / mortality
Humans
Lung Diseases, Interstitial / etiology*
Lung Diseases, Interstitial / mortality
Pneumonia / etiology
Pneumonia / mortality