Preparation, physicochemical characterization and pharmacological study of novel ruthenium(III) complexes with imidazole and benzimidazole derivatives

Arzneimittelforschung. 2001 Sep;51(9):758-62. doi: 10.1055/s-0031-1300111.

Abstract

Complex compounds of ruthenium(III) with 1,2-dimethylimidazole (CAS 1739-84-0), 2-phenylimidazole (CAS 670-96-2) and 2-aminobenzimidazole (CAS 934-32-7) were prepared and were characterised by physicochemical methods. Coordination sites were determined. The complexes were tested for cytotoxic activity using MTT (3-(4,5-dimethyithiazol-2-yl)-2,5-diphenyltetrazolium bromide) dye-reduction assay and the values LD50 were evaluated.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Benzimidazoles / chemical synthesis*
  • Benzimidazoles / pharmacology*
  • Burkitt Lymphoma / drug therapy
  • Cell Survival / drug effects
  • Chemical Phenomena
  • Chemistry, Physical
  • Drug Screening Assays, Antitumor
  • Humans
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology*
  • Indicators and Reagents
  • Lethal Dose 50
  • Male
  • Mice
  • Ruthenium / chemistry*
  • Ruthenium / pharmacology*
  • Spectrophotometry, Infrared
  • Tetrazolium Salts
  • Thiazoles
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Benzimidazoles
  • Imidazoles
  • Indicators and Reagents
  • Tetrazolium Salts
  • Thiazoles
  • Ruthenium
  • thiazolyl blue