Design and synthesis of potent and selective inhibitors of integrin VLA-4

Bioorg Med Chem Lett. 2001 Nov 19;11(22):2955-8. doi: 10.1016/s0960-894x(01)00586-8.

Abstract

The synthesis and identification of a novel series of inhibitors of integrin VLA-4 are described. Their in vitro activity and selectivity against closely related integrins are also presented.

MeSH terms

  • Anti-Allergic Agents / antagonists & inhibitors*
  • Drug Design
  • Integrin alpha4beta1
  • Integrins / antagonists & inhibitors*
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Peptides / pharmacology
  • Receptors, Lymphocyte Homing / antagonists & inhibitors*
  • Receptors, Very Late Antigen / antagonists & inhibitors*
  • Structure-Activity Relationship
  • Urea / chemistry

Substances

  • Anti-Allergic Agents
  • Integrin alpha4beta1
  • Integrins
  • Peptides
  • Receptors, Lymphocyte Homing
  • Receptors, Very Late Antigen
  • Urea