[Inclusion body myositis associated with sacroidosis: a report of 3 cases]

Ann Pathol. 2001 Aug;21(4):334-6.
[Article in French]

Abstract

Inclusion body myositis (IBM) is a severe form of idiopathic inflammatory myopathy. A predominantly T CD8+ lymphocytic infiltrate, with focally non-necrotizing muscular fiber invasion, and rimmed-vacuoles are specific histological signs. A few cases of IBM associated with other dysimmune diseases have been reported, but only once with systemic sarcoidosis. We report three cases of muscular sarcoidosis associated with IBM. This very uncommon observation suggests that major complex of histocompatibility, soluble factors, cytokines and adhesion molecules could be involved. Our cases are a novel example of associated dysimmune diseases.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Biopsy
  • CD8-Positive T-Lymphocytes / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle Fibers, Skeletal / pathology
  • Muscular Diseases / complications*
  • Muscular Diseases / pathology
  • Myositis, Inclusion Body / complications
  • Myositis, Inclusion Body / pathology*
  • Sarcoidosis / complications*
  • Sarcoidosis / pathology
  • Vacuoles / pathology