Keratitis caused by Candida glabrata in a patient with chronic granulomatous disease

Am J Ophthalmol. 2001 Nov;132(5):782-3. doi: 10.1016/s0002-9394(01)01091-1.

Abstract

Purpose: To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease.

Methods: Interventional case report. A 15-year-old boy with chronic granulomatous disease presented with bilateral limbal infiltrates. He had been receiving broad-spectrum systemic antibiotics for recurrent liver abscesses. The keratitis did not respond to antibiotics and did not resolve after a course of topical steroids.

Results: Corneal cultures revealed Candida glabrata. The same species was simultaneously isolated from the surgical drainage of the liver abscesses. The ocular and hepatic findings resolved on intravenous amphotericin B.

Conclusion: Candida glabrata has recently emerged as an important nosocomial pathogen. It may present as a limbal keratitis in the setting of systemic infection.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Candida / isolation & purification
  • Candidiasis / complications*
  • Candidiasis / diagnosis
  • Candidiasis / drug therapy
  • Cornea / microbiology
  • Eye Infections, Fungal / diagnosis
  • Eye Infections, Fungal / drug therapy
  • Eye Infections, Fungal / etiology*
  • Granulomatous Disease, Chronic / diagnosis
  • Granulomatous Disease, Chronic / drug therapy
  • Granulomatous Disease, Chronic / microbiology*
  • Humans
  • Keratitis / diagnosis
  • Keratitis / drug therapy
  • Keratitis / microbiology*
  • Liver Abscess / diagnosis
  • Liver Abscess / drug therapy
  • Liver Abscess / microbiology
  • Male
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / microbiology
  • Visual Acuity

Substances

  • Antifungal Agents
  • Amphotericin B