Multidrug resistant Mycobacterium leprae from patients with leprosy

Antimicrob Agents Chemother. 2001 Dec;45(12):3635-9. doi: 10.1128/AAC.45.12.3635-3639.2001.

Abstract

Sequences of the folP1, rpoB, and gyrA genes were analyzed for 88 isolates of Mycobacterium leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates (14.8%) showed representative mutations in more than two genes, suggesting the emergence of multidrug-resistant M. leprae.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacology
  • Anti-Infective Agents / therapeutic use
  • Antibiotics, Antitubercular / pharmacology
  • Antibiotics, Antitubercular / therapeutic use
  • Base Sequence
  • DNA Primers
  • DNA, Bacterial / drug effects
  • DNA, Bacterial / genetics
  • Drug Resistance, Microbial
  • Drug Resistance, Multiple
  • Genes, Bacterial / drug effects
  • Genes, Bacterial / genetics
  • Humans
  • Leprostatic Agents / pharmacology*
  • Leprostatic Agents / therapeutic use*
  • Leprosy / drug therapy*
  • Leprosy / microbiology*
  • Mice
  • Molecular Sequence Data
  • Mycobacterium leprae / drug effects*
  • Mycobacterium leprae / genetics
  • Ofloxacin / pharmacology
  • Ofloxacin / therapeutic use
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rifampin / pharmacology
  • Rifampin / therapeutic use

Substances

  • Anti-Infective Agents
  • Antibiotics, Antitubercular
  • DNA Primers
  • DNA, Bacterial
  • Leprostatic Agents
  • Ofloxacin
  • Rifampin

Associated data

  • GENBANK/AL023093
  • GENBANK/Z14314
  • GENBANK/Z70722