Abstract
In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / pharmacology*
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Cell Line
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Delavirdine / analogs & derivatives*
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Delavirdine / chemical synthesis*
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Delavirdine / pharmacology*
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Drug Evaluation, Preclinical / methods
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Drug Evaluation, Preclinical / statistics & numerical data
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HIV-1 / drug effects*
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Humans
Substances
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Anti-HIV Agents
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Delavirdine