TNF cytokine family: more BAFF-ling complexities

Curr Biol. 2001 Dec 11;11(24):R1013-6. doi: 10.1016/s0960-9822(01)00613-3.

Abstract

Recent studies on BAFF, a member of the tumor necrosis factor family, and the discovery of a new BAFF receptor have revealed that this ligand-receptor pair is essential for B-cell survival and differentiation, holding promise for a better understanding and treatment of some autoimmune diseases and lymphomas.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Cell Activating Factor
  • B-Lymphocytes / cytology
  • Cell Survival / physiology
  • Membrane Proteins / metabolism*
  • Membrane Proteins / physiology
  • Mice
  • Tumor Necrosis Factor-alpha / metabolism*
  • Tumor Necrosis Factor-alpha / physiology

Substances

  • B-Cell Activating Factor
  • Membrane Proteins
  • Tnfsf13b protein, mouse
  • Tumor Necrosis Factor-alpha