Brain development: integrins and the Reelin pathway

Curr Biol. 2001 Dec 11;11(24):R1032-5. doi: 10.1016/s0960-9822(01)00618-2.

Abstract

Integrins link the extracellular matrix to the intracellular environment. They have been implicated in the Reelin pathway in cortical development. But new genetic studies have revealed that, while beta(1) integrin plays a role in formation of the basement membrane, it is not essential for neuronal migration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / growth & development*
  • Cell Adhesion Molecules, Neuronal / physiology*
  • Extracellular Matrix Proteins / physiology*
  • Integrins / physiology*
  • Mice
  • Nerve Tissue Proteins
  • Reelin Protein
  • Serine Endopeptidases

Substances

  • Cell Adhesion Molecules, Neuronal
  • Extracellular Matrix Proteins
  • Integrins
  • Nerve Tissue Proteins
  • Reelin Protein
  • Reln protein, mouse
  • Serine Endopeptidases