Abstract
Pseudomonas aeruginosa isolates from an outbreak in Canada were highly resistant to carbapenems and ceftazidime but not piperacillin. They produced a novel integron-associated metallo-beta-lactamase, designated IMP-7, with 91% identity to IMP-1. bla(IMP-7) was not detected with standard bla(IMP)-specific primers, owing to mismatches in the forward primer.
MeSH terms
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Amino Acid Sequence
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Canada / epidemiology
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Carbapenems / pharmacology
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Cross Infection / epidemiology
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Disease Outbreaks*
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Humans
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Molecular Sequence Data
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Pseudomonas Infections / epidemiology*
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / enzymology
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Pseudomonas aeruginosa / genetics*
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Sequence Homology, Amino Acid
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Spermidine / analogs & derivatives*
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Spermidine / pharmacology
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beta-Lactam Resistance / genetics*
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beta-Lactamases / genetics
Substances
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Carbapenems
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FR 160
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beta-lactamase IMP-1
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beta-Lactamases
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Spermidine