[Immunohistochemical study of vascular endothelial growth factor, relative receptors and ligands in vascular endothelial cells of cerebral arteriovenous malformation]

Zhonghua Wai Ke Za Zhi. 2001 Sep;39(9):675-8.
[Article in Chinese]

Abstract

Objective: To study morphologically the formation, growth and rupture of cerebral arterivenous malformation (CAVM).

Method: By means of immunostaining we studied vascular endothelial growth factor (VEGF), Tie-1, Tie-2, Ang-1, Ang-2 in endothelial cells (EC) of CAVM (30 specimens) and control cortical vessel (7 specimens) in the temporal lobe.

Results: The expression of VEGF in EC of CAVM was -884, +1,819, + +424 and in controls -445, +29, + +10. The expression of Tie-1 in EC of CAVM was -2,252, +626, + +12 and in controls -421, +88, + +6. The expression of Tie-2 in EC of CAVM was -683, +1,908, + 8 and in controls -444, +64, + +7. The expression of Ang-1 in EC of CAVM was -2,215, +209, + +41 and in controls -487, +41, + +9. The expression of Ang-2 in EC of CAVM was -956, +2,099, + +135 and in controls -475, , + +9.

Conclusion: Up-regulated VEGF in part of brain and Tie-2, Ang-2 high expression in EC of some vessels may be one of major factors for CAVM formation growth, and rupture in the embryonic period.

Publication types

  • English Abstract

MeSH terms

  • Angiopoietin-1
  • Angiopoietin-2
  • Endothelial Growth Factors / analysis*
  • Endothelium, Vascular / chemistry*
  • Endothelium, Vascular / cytology
  • Humans
  • Immunohistochemistry
  • Intracranial Arteriovenous Malformations / metabolism*
  • Lymphokines / analysis*
  • Membrane Glycoproteins / analysis*
  • Proteins / analysis*
  • Receptor Protein-Tyrosine Kinases / analysis*
  • Receptor, TIE-1
  • Receptor, TIE-2
  • Receptors, Cell Surface / analysis*
  • Receptors, TIE
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Angiopoietin-1
  • Angiopoietin-2
  • Endothelial Growth Factors
  • Lymphokines
  • Membrane Glycoproteins
  • Proteins
  • Receptors, Cell Surface
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Receptor Protein-Tyrosine Kinases
  • Receptor, TIE-1
  • Receptor, TIE-2
  • Receptors, TIE