[Chromosome locus of ATRA-induced gene RA109 and intracellular localization of RA109 protein]

Zhonghua Zhong Liu Za Zhi. 2001 Mar;23(2):100-2.
[Article in Chinese]

Abstract

Objective: To define chromosome locus of ATRA-induced gene RA109 and intracellular localization of its encoding protein.

Methods: Chromosome locus was defined by radiation hybrid mapping method and protein localization by green fluorescence protein (GFP) as reporter molecule.

Results: RA109 gene was mapped to chromosome 5q35 and its protein was localized in cell nucleus.

Conclusion: RA109 gene is mapped by radiation hybrid technique to a chromosome region that is rich in disease-related genes. The RA 109-encoding protein is a nucleoprotein.

Publication types

  • English Abstract

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 5 / genetics
  • Gene Expression Regulation / drug effects
  • Green Fluorescent Proteins
  • Humans
  • Luminescent Proteins / genetics
  • Luminescent Proteins / metabolism
  • Nucleoproteins / genetics*
  • Nucleoproteins / metabolism
  • Radiation Hybrid Mapping
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / metabolism
  • Tretinoin / pharmacology*
  • Tumor Cells, Cultured

Substances

  • Luminescent Proteins
  • Nucleoproteins
  • Recombinant Fusion Proteins
  • Green Fluorescent Proteins
  • Tretinoin