The association of AV nodal reentry tachycardia and interatrial septal defect has not been described previously. This article reports a 47-year-old woman with an atrial septal defect (ostium secundum) and history of palpitations without documental tachycardia through resting and ambulatory electrocardiography. Rapid atrial pacing under the influence of isoproterenol, during an electrophysiology study, elicited and AV nodal reentry tachycardia of the common type. Successful radiofrequency catheter ablation was performed targeting the slow pathway. Immediately an Amplatzer device was used for closure of the septal defect. Both procedures were successful and without complications. What makes this case unusual is that both interventional procedures were performed during the same session.