Association studies of cytosolic phospholipase A2 polymorphisms and schizophrenia among two independent family-based samples

Psychiatr Genet. 2001 Dec;11(4):207-12. doi: 10.1097/00041444-200112000-00005.

Abstract

An association between the cytosolic phospholipase A2 locus (cPLA2) and schizophrenia has been reported using two polymorphic DNA markers. In an attempt to replicate these results, two independent family-based samples were ascertained from the United States and India (86 and 159 families, respectively). No significant associations were detected in either sample.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Black People / genetics
  • Black or African American
  • Chi-Square Distribution
  • Cytosol / enzymology
  • DNA Primers
  • Family
  • Gene Frequency
  • Genotype
  • Group IV Phospholipases A2
  • Humans
  • Phospholipases A / genetics*
  • Phospholipases A2
  • Poly A / genetics
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Schizophrenia / enzymology
  • Schizophrenia / genetics*
  • United States
  • White People / genetics

Substances

  • DNA Primers
  • Poly A
  • Phospholipases A
  • Group IV Phospholipases A2
  • Phospholipases A2