Effect of the antiulcer polysaccharide fraction from Bupleurum falcatum L. on the healing of gastric ulcer induced by acetic acid in rats

Phytother Res. 2002 Feb;16(1):91-3. doi: 10.1002/ptr.986.

Abstract

An antiulcer polysaccharide fraction (BR-2) from Bupleurum falcatum L. was examined for its effect on the healing of chronic ulcers induced by acetic acid in rats. When BR-2 was administered orally to the rats, it was shown to be effective in the healing of acetic acid-induced chronic ulcer. This result suggests that the use of herbal prescriptions containing B. falcatum L. may prove useful for the treatment of peptic ulcers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid / toxicity
  • Animals
  • Anti-Ulcer Agents / pharmacology*
  • Anti-Ulcer Agents / therapeutic use
  • Bupleurum*
  • Dose-Response Relationship, Drug
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / pathology
  • Male
  • Peptic Ulcer / chemically induced
  • Peptic Ulcer / drug therapy*
  • Phytotherapy*
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Roots / chemistry
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Rats
  • Rats, Wistar

Substances

  • Anti-Ulcer Agents
  • Plant Extracts
  • Polysaccharides
  • Acetic Acid