Abstract
Two new sesquiterpene esters, 1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran (1) and 1beta-acetoxyl-2beta,6alpha,9alpha-trifuroyloxydihydro-beta-agarofuran (2), together with four known sesquiterpene esters (3-6), celastrol (7), and celaphanol A (8) were isolated from the roots of Celastrus orbiculatus in a search for inhibitors of NF-kappaB activation and nitric oxide production. Compound 7 was the most active, while compounds 1, 2, 4, and 8 showed moderate inhibition in both NF-kappaB activation and nitric oxide production.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Celastraceae / chemistry*
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Cells, Cultured / drug effects
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Chromatography, High Pressure Liquid
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Dose-Response Relationship, Drug
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Inhibitory Concentration 50
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Korea
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Mice
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Molecular Conformation
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Molecular Structure
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NF-kappa B / antagonists & inhibitors
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Nitric Oxide / biosynthesis
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Nitric Oxide Synthase / metabolism*
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Plasmids / metabolism
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Stereoisomerism
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Structure-Activity Relationship
Substances
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1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran
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1beta-acetoxyl-2beta,6alpha,9alpha-trifuroyloxydihydro-beta-agarofuran
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Anti-Inflammatory Agents, Non-Steroidal
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Lipopolysaccharides
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NF-kappa B
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Sesquiterpenes
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celaphanol A
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Nitric Oxide
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Nitric Oxide Synthase