Abstract
Based on recent advances in techniques that can detect and enumerate antigen-specific CD8+ T cells, it is evident that these cells can differentially regulate CD8+ T cell effector mechanisms at the single-cell level. Interplay between effector mechanisms that are employed by antigen-specific CD8+ T cells during the immune response in vivo can be addressed with different techniques that "count" cells either directly (T cell receptor (TCR) expression) or indirectly (antigen-specific cytokine production).
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens / metabolism
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CD8-Positive T-Lymphocytes / immunology*
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Cytokines / biosynthesis
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Cytotoxicity, Immunologic
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Humans
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Immunologic Techniques
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In Vitro Techniques
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Interferon-gamma / biosynthesis
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Leukocyte Count
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Mice
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Receptors, Antigen, T-Cell / metabolism
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Antigens
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Cytokines
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Receptors, Antigen, T-Cell
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Tumor Necrosis Factor-alpha
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Interferon-gamma