Discovery in toxicology: mediation by gene expression array technology

J Biochem Mol Toxicol. 2001;15(5):231-42. doi: 10.1002/jbt.10006.

Abstract

Toxicogenomics is a term that represents the merging of toxicology with novel genomics techniques. Data generated in the new-age era of toxicology is relatively complex, requires new bioinformatics tools for adequate interpretation, and allows for the rapid generation of testable hypotheses. Hazard identification and risk assessment processes will advance from the use of genomics techniques, which will lead to greater understanding of mechanism(s) of action of toxicants, development of novel biomarkers of exposure and effect, and better identification of sensitive subpopulations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA, Complementary
  • Gene Expression Profiling*
  • Humans
  • Oligonucleotide Array Sequence Analysis*
  • Polymorphism, Genetic
  • Risk Assessment
  • Toxicology*

Substances

  • DNA, Complementary