An efficient organometallic approach to new carbocyclic nucleoside analogues

Org Lett. 2002 Feb 21;4(4):565-8. doi: 10.1021/ol017181+.

Abstract

[reaction: see text] A general synthetic approach to monoprotected carbocyclic nucleoside analogues, having the nucleobase attached to a 3-hydroxymethyl-4-trialkylsilyloxymethyl-cyclopent-2-en-1-yl scaffold, was developed. A (racemic) key intermediate was prepared by a cobalt-mediated Pauson-Khand reaction. In the course of the further synthesis, the introduction of the nucleobase was achieved with complete regio- and diastereoselectivity through a palladium-catalyzed allylic substitution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / chemical synthesis*
  • Crystallography, X-Ray
  • Indicators and Reagents
  • Models, Molecular
  • Nucleosides / chemical synthesis*
  • Nucleosides / chemistry
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry

Substances

  • Antibiotics, Antineoplastic
  • Indicators and Reagents
  • Nucleosides
  • Organometallic Compounds