Synthesis, antimicrobial and molluscicidal activities of new benzimidazole derivatives

Arch Pharm Res. 2002 Feb;25(1):28-38. doi: 10.1007/BF02975257.

Abstract

A series of benzimidazole Schiff's bases, thiosemicarbazides were synthesized, azole ring systems as 1,3,4-triazole, 1,3,4-oxadiazole were prepared. 1-Methylbenzimidazole incorporated to substituted dithio-carbamate, thiophenol, diethylamine via acetamido group were synthesized. A series of pyrimidinobenzimidazoles, triazinobenz-imidazoles, and 2-(acetonylamino)-1-methylbenzimidazole were prepared. The antimicrobial and molluscicidal activities of some newly prepared compounds were carried out.

MeSH terms

  • Animals
  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / pharmacology*
  • Bacteria / drug effects*
  • Benzimidazoles / chemical synthesis*
  • Benzimidazoles / pharmacology*
  • Benzimidazoles / toxicity
  • Biomphalaria / physiology*
  • Chemical Phenomena
  • Chemistry, Physical
  • Culture Media
  • Fungi / drug effects
  • Indicators and Reagents
  • Lethal Dose 50
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molluscacides / chemical synthesis*
  • Molluscacides / toxicity*
  • Spectrophotometry, Infrared

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Benzimidazoles
  • Culture Media
  • Indicators and Reagents
  • Molluscacides